All Posts: breast cancer
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An Overlooked Hormone Eyed as Deadly Driver of Postmenopausal Breast Cancer in Women with Obesity
A new analysis of research into the most common type of breast cancer has zeroed in on an overlooked hormone that may be responsible for the increased risk of breast cancer death in postmenopausal women with obesity. It also raises the possibility that treatment of these aggressive breast cancers could be improved with the addition of weight-loss drugs known as GLP-1 receptor agonists.
Category: News Release
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Celebrating a Milestone in Cancer Research
This month marks the 50th anniversary of the publication of a paper by now-Georgetown Lombardi member Marc E. Lippman, MD, MACP, FRCP, and his colleague Gail Bolan, MD, that showed for the first time that the hormone estrogen can drive the growth of breast cancer. It was a pivotal moment in cancer research that has led to life-extending and lifesaving treatments for the thousands of people who develop breast cancer each year.
Category: GUMC Stories
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ISPY2: A Unique, Flexible Breast Cancer Trial for Modern Times
The ISPY2 breast cancer clinical trial is a unique phase 2 study that offers a broad range of treatment options for patients with locally advanced breast cancer.
Category: GUMC Stories
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The Aspirin Conundrum: Navigating Negative Results, Age, Aging Dynamics and Equity
A new study examining the role of aspirin in breast cancer treatment reveals critical issues related to health equity and aging that have broad implications for cancer and other disease intervention trials, say researchers from Georgetown University’s Lombardi Comprehensive Cancer Center. They outline their concerns in an editorial accompanying the study’s findings published April 29 in the JAMA.
Category: News Release
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Biology Behind New Drug Used to Treat Triple-Negative Breast Cancer Uncovered
How TTP488 (azeliragon), an experimental drug, impairs aggressive, triple-negative breast cancer from metastasizing has been uncovered at the cellular level, according to researchers at Georgetown University’s Lombardi Comprehensive Cancer Center.
Category: News Release
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Research To Help Patients Make Informed Decisions About Breast MRI
While many people think that breast cancer screening and mammography are synonymous, Claire Conley, PhD, wants people to know that women who are at higher than average risk for breast cancer may also receive a breast MRI.
Category: GUMC Stories
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Women with Elevated Breast Cancer Risk Could See Mortality Benefit from Estrogen-Blocking Drugs
While it has long been recognized that drugs that block the cancer-promoting activity of estrogen reduce the risk of developing new breast cancers, a new computer modeling study led by researchers at Georgetown Lombardi Comprehensive Cancer Center and colleagues showed that these treatments could also reduce the risk of dying from the disease in women who are at high risk.
Category: News Release
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Study in Mice Suggests that Expression of Estrogen-Related Gene Can Impact Postmenopausal Breast Cancer Risk and Prevention Strategies
In a study using a first-of-its-kind mouse model of aging that mimics breast cancer development in estrogen receptor-positive postmenopausal women, investigators at Georgetown Lombardi Comprehensive Cancer Center and colleagues have determined that over-expression, or switching on, of the Esr1 gene could lead to elevated risk of developing estrogen receptor-positive breast cancer in older women.
Category: News Release
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‘Lombardi Women’ Event Brings Together Local Businesswomen to Support Breast Cancer Research
Category: GUMC Stories
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Long-term Study Supports Link Between Inflammation and Cognitive Problems in Older Breast Cancer Survivors
Category: News Release