(Back to TOP )

Esbensen, Kari

(Current Student - Philosophy/Bioethics)

Journal Publications:

• McAbee DD; Nowatzke W; Oehler C; Sitaram M; Sbaschnig E; Opferman JT; Carr J; Esbensen KL.  Endocytosis and Degradationi of Bovine Apo- and Holo-lactoferrin by Isolated Rat Hepatocytes Are Mediated by Recycling Calcium-Dependent Binding Sites.  Biochemistry 32: 13749-13760, 1993.
  
  
• McAbee DD; Esbensen KL.  Binding and Endocytosis of Apo- and Holo-Lactoferrin by Isolated Rat Hepatocytes. J Biol Chem 266:23624-23632, 1991.

Abstracts:

• Herr J; Esbensen KL; Flickinger C.  Cover Photo (Immunohistochemical localization of SP-10 in baboon testis)  Amer J Reprod Immunol 31, 1994.

(Back to TOP )

Feltes, Carolyn Feltes>

(Graduated 2003 - Cell Biology)

Doctoral Dissertation:

• Significance and function of cadherin-11 in breast cancer   

Journal Publications:

• Pishvaian MJ; Feltes CM; Thompson P; Bussemakers MJ;  Schalken JA;  Byers SW.  Cadherin-11 is Expressed in Invasive Breast Cancer Cell Lines.  Canc Res (in press).

(Back to TOP )

Fenster, Bradley D.

(Graduated 1996 - Biochemistry & Molecular Biology)

Doctoral Dissertation:

• The Effects of Protein Kinase A on Estrogen Receptor Expression and Activity (Steroid Hormones, Signal Transduction)   

(Back to TOP )

Frye, Richard E.

(Graduated 1998 - Physiology & Biophysics)

Doctoral Dissertation:

• Computational models of stereo vision with applications to optimal stereo x-ray imaging    

Journal Publications:

• Frye RE; Rosin DF; Doty RL; Morrison A.  The nasal cycle:  relationship to sleep stage and body position.  Resp Physiol (submitted).
  
  
• Frye RE; Doty RL; Deems DA.  The nasal cycle:  affect of food intake on asymmetric autonomic activity.  J Appl Physiol (submitted).
  
  
• McKeown DA; Doty RL; Perl DP; Frye RE; Simms I; Mester A.  Olfactory function in young adolescents with Down?s syndrome.  J urol Neurosurg Psychiatry 61:412-4, 1996.
  
  
• Frye RE.  Airway dynamics and olfactory function.  In (Ed) Doty, R.  Handbook of Clinical Olfaction and Gustation, Section II:  Olfaction, Sub-Section C:  Clinical applications and perspectives.471-491, 1995.
  
  
• Frye RE; Doty RL; Shaman P.  Bilateral and unilateral olfactory sensitivity:  relationship to handedness, gender and nasal resistance.  In R.L. Doty and D. Muller-Schwarze  (Eds.), Chemical Signals in Vertebrates VI, 559-64, 1992.
  
  
• Frye RE; Doty RL. The influence of ultradian autonomic rhythms as indexed by the nasal cycle on unilateral olfactory thresholds.  In R.L. Doty and D. Muller-Schwarze  (Eds.), Chemical Signals in Vertebrates VI, 595-8, 1992.
  
  
• Frye RE; Doty RL.  A comparison of response characteristics of airflow and pressure transducers commonly used in rhinomanometry.  IEEE Trans Biomed Eng 37:  937-44, 1990.
  
  
• Doty RL; Kreiss DS; Frye RE.  Human odor intensity perception:  correlation with frog epithelial adenylate cyclase activity and transepithelial voltage response.  Brai Res 527: 130-4, 1990.
  
  
• Frye RE; Schwartz B; Doty RL.  Dose-related effects of cigarette smoking on olfactory function.  JAMA  9:1233-6, 1989.
  
  
• Doty RL; Frye RE; Agrawal U.  Internal consistency reliability of the fractionated and whole University of Pennsylvania Smell Identification Test.  Percept Psychophys 45: 381-4, 1989.
  
  
• Schwartz B; Dot, RL; Monroe C; Frye RE; Barker S. Alterations in olfactory function in industrial chemical workers exposed to ethyl acrylate.  Am J Public Health  79: 613-618, 1989.
  
  
• Doty RL; Frye RE.  Influence of nasal obstruction on smell function.  In C.P. Kimmelman (Ed.), Otolaryngol Clin North Am 22: 397-411, 1989.
  
  
• Doty RL; Deems DA; Frye RE; Pelberg R; Shapiro A.  Olfactory sensitivity, nasal resistance, and autonomic function in patients with multiple chemical sensitivities.  Arch Otolaryngol Head Neck Surg 114:1422-7, 1988.
  
  
• Mester AF; Doty RL; Shapiro A; Frye RE.  Influence of body tilt within the sagittal plane on odor identification performance.  Aviat Space Environ Med 59: 734-7, 1988.

Abstracts:

• Ledley RS; Frye RE.  Processing of stereo image pairs: rlimination of depth planes using the 'Cut Plane' procedure.  Proceedings of the Society for Imaging Science and Technology and the International Society for Optical Engineering Symposium on Electronic Imaging Science and Technology 2177:66-77, 1994.
  
  
• Frye RE; Doty RL; Mester A; Platt K; Gonzalez J.  Mathematical models of the nasal airway:  ability to discriminate between normal and abnormal static resistive components.  Proceedings of the Sixteenth Annual Northeast Bioengineering Conference, 117-118, 1990.

(Back to TOP )

Fryer, Robert H.

(Graduated 1996 - Cell Biology)

Doctoral Dissertation:

• Developmental Expression, Cellular Localization, and Possible Roles of Full Length and Truncated TRKB Receptors in the Rodent CNS (Neurotrophins)    

(Back to TOP )

Guerdino (Hastings), Alice 

(Graduated 1997 - Microbiology & Immunology)

Doctoral Dissertation:

• An analysis of the trimolecular interaction between T cell receptor, myelin basic protein, and HLA-DR(alpha,beta(1)*1301)    

Journal Publications:

• Hastings AE; Hurley CK; Robinson ED; Salerno K; Hernandez E; Richert JR.  Molecular interactions between transfected human TCR, immunodominant myelin basic protein peptide 152-165, and HLA-DR13.  J Immunol 157:3460-71, 1996.
  
  
• Posch PE; Hastings AE; Rosen-Bronson S; Richert JR; Hurley CK.  The relative importance of individual DR binding motif positions as defined by peptide anchor analysis of influenza hemagglutinin peptide 306-318 and human myelin basic protein peptide 152-165 binding to several DR molecules: definition of a common extended DR binding motif.  Eur J Immunol 26:1884-91, 1996.
  
  
• Hastings AE; Robinson ED; Hurley CK; Richert JR.  Development of a transfection system for myelin basic protein-specific human alpha beta T-cell receptors.  Ann NY Acad Sci 756:321-2, 1995.
  
  
• Wade JA; Hurley CK; Hastings AE; Ehrenberg P; Johnson AH; Martell RW; du Toit ED.  Combinatorial diversity in DR2 haplotypes.  Tissue Antigens 41:113-8, 1993.
  
  
• Coloma J; Hastings AE; Wims L; Morrison S.  Novel vectors for the expression of antibody molecules using variable regions generate by polymerase chain reaction (PCR).  J Immunol  Methods 152(1) : 89-104, 1992.
  
  
• Hastings AE; Morrison S; Kanda S; et al.  Production and characterization of murine/Human chimeric anti-idiotype antibody that mimic ganglioside.  Cancer Res  82:1681-1686, 1992.
  
  
• Lichenstein H; Hastings AE;  Langley K; et al.  Cloning and nucleotide sequence of the N-acetylmuramidase M1-encoding gene from streptomyces globispores.  Gene 88:81-86, 1990.

Abstracts:

• Hastings AE; Robinson ED; Hurley CK; Richert JR. Molecular interactions of HLA-DR, myelin basic protein and human TCR.  Presented at FASEB. Experimental Biology Meeting.  Atlanta, GA April 9-13, 1995.
  
  
• Hastings AE; Robinson ED; Hurley CK; Richert JR. Transfection of human ab TCR cDNAs from a myelin basic protein (MBP) - specific T cell clone. Presented at keystone symposia on molecular and cellular biology control and manipulation of the Immune Response. Taos, New Mexico, 1995.
  
  
• Elliot S; Hastings AE; Delorme E; et al.  Isolation of secretion mutants with enhanced cell surface targeting of heterolous proteins.  Yeast 4:460, 1988.
  
  
• Morrison S; Hastings AE; Wims L.  Cloning vectors for expressing PCR generated variable regions as complete heavy and/or  light chain(s), DKT.  38996
  
  
• Morrison S; Irie R; Hastings AE.  Chimerfic Murine Anti-Idiotype Monoclonal Antibodies, DKT.  85-368.

(Back to TOP )

Harris, Brent T.

(Graduated 1995 - Pharmacology)

Doctoral Dissertation:

• Glutamate Receptor Stimulation Regulates the Expression of GABA Type A Receptor Subunits and MRNAs in Primary Cultures of Rat Cerebellar Granule Neurons 

Journal Publications:

• Harris BT; Horoupian D.  Melanotic craniopharyngioma: a case report. Neuropath (submitted).
  
  
• Harris BT;  Horoupian D.  Glial heterotopia involving the parotid gland of a 2-year-old: a case report.  (in preparation).
  
  
• Harris BT; Morgan R; Dreisbach P; Horoupian DS.  Spinal neurocytoma in a 44-year-old woman. (in preparation).
  
  
• Hahn JS; Harris BT; Guiterrez K; Sandbor, C.  Progressive multifocal leukoencephalopathy in a 15-year-old boy with scleroderma and secondary amyloidosis.  Pediatrics 102:1475-9, 1998.
  
  
• Grayson DR; Zhu W; Harris BT; Vicini S; Zheng T.  Differentially expressed GABAA-receptor subunits result in structurally and functionally receptor assemblies followoing excitatory afferent synaptic transmission.  Perspect Dev Neurobiol 5:193-205, 1998.
  
  
• Huhn SL; Harris BT; Piatt JH.  A preadolescent with polydipsia and polyuria.  Pediatr Neurosurg 28:91-5, 1998.
  
  
• Zhu WJ; Vicini S; Harris BT; Grayson DR.  NMDA-mediated modulation of gamma-aminobutyric acid type A receptor function in cerebellar granule neurons.  J Neurosci 15:7692-701, 1995.
  
  
• Zhu WJ; Vicini S; Harris BT; Grayson DR.  NMDA-mediated modulation of GABA type A receptor function in cerebellar granule neurons.  J Neurosci 15:7692-701, 1995.
  
  
• Harris BT; Costa E; ad Grayson DR.  Exposure of neuronal cultures to K+ depolarization or to N-methyl-D-aspartate increases the transcription of genes encoding the a1 and a5 GABA_A receptor subunits. Mol Brain Res 28: 338-342, 1995.
  
  
• Harris BT; Charlton M; Costa E; Grayson DR.  Quantitative changes in the a1 and a5 GABA_A receptor subunit mRNAs and proteins following a single treatment of cerebellar granule neurons with N-methyl-D-aspartate. Mol Pharmacol 45: 637-648, 1994.
  
  
• Boucher BJ; Claff HR; Edmonson M; Evans S; Harris BT; Hull SA; Jones EJ; Mellins DH; Safir JG; Taylor B; et al.  A pilot Diabetic Support Service based on family practice attenders: comparison with diabetic clinics in east London.  Diabet Med 4:480-4, 1987.
  
  
• Yudkin JS; Boucher BJ; Schopflin KE; Harris BT; Claff HR; Whyte NJ; Taylor B; Mellins DH; Wootliff AB; Safir JG; Jones EJ.  The quality of diabetic care in a London health district.  J Epidemiol Community Health 34:277-80, 1980.

Abstracts:

• Harris BT; Horoupian DS; Glusker P.  Pathology of the carotid arteries in a patient with CADASIL: a case report. Proc of the American Assoc of Neuropathologists, Abstract, 1998.

(Back to TOP )

Hedvat, Cyrus V.

(Graduated 1996 - Pathology)

Doctoral Dissertation:

• The Isolation and Characterization of Minor, A Novel Mitogen-Inducible Nuclear Orphan Receptor (Steroid Hormones)    

Journal Publications:            

• Hedvat CV; Irving SI.  The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor.  Mol Endocrinol 9:1692-700, 1995.
  
  
• Dipersio J F; Hedvat CV; Ford CF; Golde DW; Gasson JC.  Characterization of the soluble human granulocyte-macrophage colony-stimulating factor receptor complex.  J Biol Chem 266:279-86,  1991.
  
  
• Avalos BR; Gasson JC; Hedvat CV; Quan SG; Baldwin GC; Weisbart RH; Williams RE; Golde DW; Dipersio JF.  Human granulocyte colony-stimulating factor:  Biologic activities and receptor characterization on hematopoietic cells and small cell lung cancer cell lines.  Blood 75:851-7, 1990.

(Back to TOP )

Jarabek, Bryan

(Current Student - Pharmacology)

Journal Publications:

• Jarabek BR; Yasuda RP; Wolfe BB.  Regulation of Proteins Affecting NMDA Receptor-Induced Excitotoxicity in a Huntington's Mouse Model.  Brain 2004 (In Press).
  
  
• Jarabek BR; Yasuda RP; Wolfe BB.  NMDA Receptors and Associated Proteins in Huntington's Disease.  LIfe Sciences, 2004 (In preparation).

(Back to TOP )

Kruklitis, Robert J.

(Graduated 1997 - Biochemistry & Molecular Biology)

Doctoral Dissertation:

• The bacteriophage Mu transposase plays a fundamental role in the establishment of a replisome for cointegrate formation   

Journal Publications:

• Kruklitis RJ.  Disassembly of the Bacteriophage Mu Tranposase for the initiation of Mu DNA Replication (submitted).
  
  
• Kruklitis RJ.  Participation of the bacteriophage MuA protein and host factors in the initiation of MU DNA synthesis in vitro.  J Biol Chem 269:16469-16477, 1994.

(Back to TOP )

Ladas, John G.

(Graduated 1996 - Physiology & Biophysics)

Doctoral Dissertation:

• Regulation of Renal Proximal Tubule Phosphate Transport During Development 

Journal Publications:

• Ladas JG; Mulroney SE; Winaver J; Haramati A. Effect of a GH-releasing factor antagonist on whole kidney and BBMV phosphate transport. Am J Physiol (submitted)
  
  
• Ladas JG; Mulroney SE; LeRoith D; Winaver J; Haramati A.  Role of effect of a GH-releasing factor antagonist on whole kidney and BBMV phosphate transport in weanling rats  (in revision).
  
  
• Phillip M; SegeveU; Zung A; Kowarski AA; Werner H; Roberts Jr CT; LeRoith D; Ladas JG; Mulroney SE.  The accumulation of IGFI in kidneys of streptozotocindiabetic adult rats is not associated with elevated plasma GH and IGFI levels.  Endocrine 3: 689-693, 1995.

Abstracts:

• Ladas JG; Mulroney SE; Haramati A. Regulation of renal proximal tubule phosphate transport during development.  Proc Soc Exp Biol Med  208:210, 1995.
  
  
• Ladas JG; Mulroney SE; Winaver J; Haramati A.  Regulation of renal proximal tubule phosphate transport during development.  FASEB J  8:A836, 1994.
  
  
• Mulroney SE; Pesce C; Striker L; Koenig JI; Ladas JG; Haramati A.  IGF-I and cFOS-associated mitogenic renal growth following uninephrectomy in weanling rats.  Proceedings of the XIIth International Congress of Nephrology, pp. 30, 1993.
  
  
• Mulroney SE; Koenig JI; Ladas JG; Haramati A.  IGF-I associated mitogenic renal growth following uninephrectomy in weanling rats.  Presented at the 4th International Symposium on Insulin, IGFs, and Their Receptors, 1993.
  
  
• Mulroney SE; Ladas JG;. Haramati A. Sexual dimorphism in compensatory renal growth after Unx.  J Am Soc Physiol, 1993.
  
  
• Ladas JG; Mulroney SE; Jiang G; Winaver J; Haramati A. Adaptation of renal Pi transport to dietary Pi deprivation in weaning rats: independence of growth hormone (GH) release.  J Am Soc Nephrol 4:710, 1993.
  
  
• Haramati A; Lumpkin MD; Winaver J; Ladas JG; Mulroney SE.  Role of growth hormone/IGF-I axis in regulating phosphate homeostasis during growth.  Proceedings of the Fifth International Workshop on Developmental Renal Physiology, 1992.
  
  
• Ladas JG; Winaver J; Mulroney SE; Haramati A.  Effect of a GH-releasing factor antagonist on phosphate uptake into proximal tubular brush border membrane vesicles from immature rats.  J Am Soc Nephrol  3:684, 1992.
  
  
• Nasir M; Ladas JG; Jose PA; Winchester J; Lumpkin MD; Mulroney SE; Haramati A. Characterization of renal growth hormone receptor in rat proximal tubules. J Am Soc Nephrol 2:43, 1991.
  
  
• Mulroney SE; Ladas JG; Roberts CT; Leroith D; Haramati A. Increased renal IGF-I and IGF-II receptor mRNA and ligand binding following uninephrectomy in immature rats. J Am Soc Nephrol 2:686, 1991.

(Back to TOP )

Livsey, Charles T.

(Graduated 1997 - Pharmcology)

Doctoral Dissertation:

• Hippocampal Rat the of Neurons Hilar Aspiny Versus Spiny in Current Mediated Receptor Glutamate Non-NMDA Differences>     

Journal Publications:

• Livsey CT; Costa E; Vicini S. Glutamate-activated currents in outside-out patches from spiny hilar neurons of rat hippocampal slices.  J Neurosci 13: 5324-5333, 1993.
  
  
• Livsey CT; Vicini S.  Slower spontaneous excitatory synaptic currents in spiny versus aspiny hilar neurons.  Neuron 8:745-755, 1992.
  
  
• Mereu G; Costa E; Livsey,CT; Vicini S. Modulation of GABA-gated Cl currents in nigral neurons in slices.  In GABAergic synaptic transmission, G Biggio, AConcas and E Costa Eds. Raven Press, New York 47: 179-188, 1992.
  
  
• Vicini S; Livsey CT; Costa E; Mereu G.  Allosteric modulators of the NMDA receptor affect excitatory post synaptic currents in a thin slice preparation of rat hippocampus.  In "Excitatory Amino Acids", BS Meldrum, F Moroni, R P Simon, and J H Wood Eds. Raven Press, New York, pp. 255-261, 1991.
  
  
• Xu X; Huang B; Livsey CT; Karwoski CJ. Comparison of pharmacological agents (aspartate vs. aminophosphonobutyric plus kynurenic acids) to block synaptic transmission from retinal photoreceptors in frogs.  Exp Eye Res 52: 691-698, 1991.
  
  
• Livsey CT; Huang B; Xu J; Karwoski C.  Light-evoked changes in extracellular calcium concentration in frog retina.  Vision Res, 30: 853-861, 1990.
  
  
• Livsey CT; Huang B; Xu J; Karwoski CJ.  Light-evoked changes in extracellular calcium concentration in frog retina.  Vision Res 30: 853-861, 1990.

(Back to TOP )

Low, Jennifer

(Graduated 1998 - Cell Biology/Tumor Biology)

Doctoral Dissertation:

• Inhibition of matrix metalloproteinases in a human breast cancer xenograft model   

Journal Publications:

• Low JA; Holst-Hansen C; Brunner N; Tobias C; McLeskey SW; Bone EA; Johnson MD; Dickson RB.  Increased stromal expression of urokinase plasminogen activator in a human breast tumor model following anti-MMP therapy (in preparation).
  
  
• Dickson RB; Johnson MD; Maemura M; Low JA.  Anti-invasion drugs.  Breast Cancer Res Treat 38:121-32, 1996.
  
  
• Low JA; Johnson MD; Bone EA; Dickson RB.  Matrix metalloproteinase inhibitor batimastat (BB-94) retards human breast cancer solid tumor growth but not ascites formation in nude mice.  Clin Cancer Res, 2: 1207-1214, 1996.
  
  
• Wojtowicz-Praga S; Low JA; Marshall J; Ness E; Dickson R; Barter J; Sale M; McCann P; Moore J; Cole A; Hawkins MJ.  Phase I trial of a novel matrix metalloproteinase inhibitor batimastat (BB-94) in patients with advanced cancer.  Invest New Drugs, 14: 193-202, 1996.
  
  
• Dickson RB; Low JA; Johnson MD; Hawkins MJ; and BJ.  Blood-borne indicators of breast cancer and their use in experimental, medical oncologic, and prevention studies.  The Breast, 5: 379-384, 1996.
  
  
• Dickson RB; Johnson MD; Maemura M; Low JA.  Anti-invasion drugs.  Breast Cancer Res Treat, 38: 121-132, 1996.
  
  
• Ehsani A; Low JA; Wallace RB; Wu A. Characterization of a new allele of the human erB2 gene by allele-specific competition hybridization. Genonics 15: 426-429, 1993.
  
  
• Hope TJ; Mc Donald D; Huang X; Low JA; Parslow TG. Mutational analysis of the HIV-1 Rev transactivator: essential residues near the amino terminus. J Virology  64: 5360-5366, 1990.

(Back to TOP )

Mandal, Aloke K.

(Graduated 1992 - Pharmacology)

Doctoral Dissertation:

• The Role of 5-HT(1A) and 5-HT(2) Receptor Activation Within the Ventrolateral Medulla in the CNS Control of Cardiorespiratory Activity (Hydroxytryptamine Receptors, Serotonin) 

(Back to TOP )

Markowski, Mark

(Current Student - Undeclared)

Journal Publications:

• Kimura K, Markowski M, Edsall LC, Spiegel S, Gelmann EP.  Role of ceramide in mediating apoptosis of irradiated LNCaP prostate cancer cells.  Cell Death Differ. 2003 Feb; 10(2):240-8.
  
  
• Kimura K, Markowski M, Bowen C, Gelmann EP.  Androgen blocks apoptosis of hormone-dependent prostate cancer cells.  Cancer Res. 2001 Jul 15;61(14):5611-8.

(Back to TOP )

Mashour, George

(Graduated 2001 - Neuroscience)

Doctoral Dissertation:

• A study of neurofibromin-deficient Schwann cells and skin: Implications for the pathogenesis and diagnosis of neurofibromatosis type 1    

Journal Publications:

• Mashour GA; Boock RJ. The effects of shear stress on the nitric oxide production of human cerebral endothelial cells (in preparation).
  
  
• Mashour GA; Cabal-Manzano R; Wellstein A; Martuza RL; Kurtz A.  Aberrant cutaneous expression of the angiogenic factor midkine is associated with neurofibromatosis type 1. J Invest Derm (in revision).
  
  
• Liu X; Mashour GA; De F; Webster H  Kurtz A.  Basic FGF and FGF receptor 1 are expressed in microglia during experimental autoimmune encephalomyelitis: temporally distinct expression of midkine. and pleiotrophin. Glia 24:390-397, 1998.
  
  
• Mashour GA; McGrail KM.  Nitric oxide and the pathogenesis of cerebral vasospasm: a brief review. J Neurovasc Dis 2(5):203-205, 1997.
  
  
• Liu X; Mashour GA; Kurtz A.  Recent developments in the treatment of encephalomyelitis. Expert Opinions on Therapeutic Patents 6(5):457-470, 1996.
  
  
• Loeffler DA; DeMaggio AJ; Juneau PL; Brickman CM; Mashour GA; Finkelman JH; Pomara NR; Lewitt PA.  Ceruloplasmin is increased in cerebrospinal fluid in Alzheimer's disease but not Parkinson's. Alzheimer Dis Assoc Disord 8:190-197, 1994.

Abstracts:

• Mashour GA; Ratner N; Cabal-Manzano R; Wellstein A; Martuza RL; Kurtz A.  The role of the angiogenic factor midkine in neurofibromatosis type 1. Oral Presentation, International Consortium for the Molecular Biology of Neurofibromatosis, Aspen, CO, 1998.
  
  
• Mashour GA.  Philosophic and neuroscientific aspects of the cognitive binding problem. Oral Presentation, Toward a Science of Consciousness Conference, Tucson, AZ, 1998.
  
  
• Mashour GA.  Growth factors in NF: implications for diagnosis and treatment. Oral Presentation, Neurofibromatosis, INC. Mid-Atlantic Meeting, NIH, Bethesda, MD, 1997.
  
  
• Mashour GA; Ratner N; Martuza RL; Wellstein A; Kurtz A.  Midkine is differentially expressed in neurofibromin-deficient Schwann cells and human neurofibromas. Society for Neuroscience 27th Annual Meeting 23(1):43.10. 1997.
  
  
• Mashour GA.  The theory of relativity and the cognitive binding problem. Oral Presentation, Toward a Science of Consciousness Conference, Helsignor, Denmark, 1997.
  
  
• Lewitt PA; Loeffler DA; Nguyen H; DeMaggio AJ; Mashour GA; Brickman CM; Kanaley L.  Ceruloplasmin concentration in control and neurodegenerative disease brain regions. Neurology 45(4):A473, 1995.
  
  
• Mashour GA; Corthesy ME; Cummin A; Laske D; Oldfield EH.  Attenuating MPTP-induced Parkinsonism in the Rhesus monkey: two neurosurgical approaches. Poster Day, NIH, 1994.

Other:

• Mashour GA.  A pawn in a conspiracy? Nature 392:221, 1998 (letter).

(Back to TOP )

Mattie, Mark E.

(Graduated 1995 - Biochemistry & Molecular Biology)

Doctoral Dissertation:

• Sphingosine-1-Phosphate and Calcium Mobilization   

Journal Publications:

• Mattie ME.  Sphingosine - 1 - Phosphate, a breakdown product of sphingolipids, regulates phosphatidic acid levels in swiss 3T3  fibroblasts.  J Biol Chem (in press).
  
  
• Mattie ME.  Sphingosine - 1-Phosphate mobilizes intracellular Ca2+ pools via booth IB3 dependent and independent pathways.  J Biol Chem (in press).
  
  
• Goodemote KA; Mattie ME; Berger A; Spiegel S.  Involvement of a pertussis toxin-sensitive G protein in the mitogenic signaling pathways of sphingosine 1-phosphate.  J Biol Chem 270: 10272-7, 1995.
  
  
• Olivera A; Zhang H; Carlson RO; Mattie ME; Schmidt RR; Spiegel S. Stereospecificity of sphingosine-induced intracellular calcium mobilization and cellular proliferation.  J Biol Chem  269:17924-17930, 1994.
  
  
• Mattie ME; Brooker G; Spiegel S. Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol triphosphate-independent pathway.  J Biol Chem  26:3181-3188, 1994.
  
  
• Desai NN; Carlson RO; Mattie ME; Olivera A; Buckley NE; Seki T; Brooker G; Spiegel S.  Signaling pathways for sphingosylphosphorycholine-mediated mitogenesis in Swiss 3T3 fibroblasts.  J Cell Biol 121: 1385-95, 1993.
  
  
• Desai NN; Zhang H; Olivera A; Mattie ME; Spiegel S.  Sphingosine-l-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation.  J Biol Chem 267: 23122-8, 1992.
  
  
• Reid LD; Marglin SH; Mattie ME; Hubbell CL.  Measuring morphine?s capacity to establish a place preference.  Pharmcol Biochem Behav  33: 765-75, 1989.
  
  
• Marglin SH; Milano WC; Mattie ME; Reid LD.  PCP and conditioned place preferences.  Pharmacol Biochem Behav  33: 281-3, 1989.
  
  
• Marglin SH; MacKechnie DK; Mattie ME; Hui YH; Reid LD.  Ethanol with small doses of morphine establishes a conditioned place preference.  Alcohol 5:309-313, 1988.

Other:

• Mattie ME.  Three dimensional image generation using optical integration.  Patent Pending, 1987.

(Back to TOP )

McDonnell, Kevin

(Graduated 1997 - Physiology & Biophysics)

Doctoral Dissertation:

• Hypothalamic Mechanisms of Ultrashort-Loop Feedback of Growth HOrmone-Releasing Hormone Secretion 

(Back to TOP )

McGaffin, Kenneth

(Graduated 1999 - Tumor Biology)

Doctoral Dissertation:

• Regulation of growth and EGF receptor expression in breast cancer cells by antiestrogens, chemotherapeutics, vitamin D, and retinoids   

Journal Publications:

• McGaffin KR;   Chrysogelos SA.  Identification and Characterization of a Response Element in the EGFR Promoter that Mediates Transcriptional Repression by 1,25-dihydroxyvitamin D₃ in Breast Cancer Cells.  Molecular Endocrinology (in revision).
  
  
• McGaffin KR; Atkinson LE; Chrysogelos SA.  Regulation of Growth and EGFR Expression in Breast Cancer Cells by Retinoids and Vitamin D Compounds (submitted).
  
  
• Saceda M; McGaffin KR; Sholler P; Fakhro A; Martin MB.  Temperature regulation of estrogen receptor in MCF-7 cells (in preparation).
  
  
• Yan CY; McGaffin KR; Van Dyke TA. Spatial and temporal regulation of the transthyretin transgenes in the developing mouse embryo (in preparation).

Other:

• McGaffin KR.  Regulation of Growth and EGF Receptor Expression in Breast Cancer Cells by Antiestrogens, Chemotherapeutics, Vitamin D, and Retinoids (Epidermal Growth Factor, Gene Expression, Cell Proliferation).  Doctoral thesis, Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, 1997.
  
  
• McGaffin KR; Chrysogelos SA.  Identification and Characterization of a Response Element in Epidermal Growth Factor Promoter that Mediates Transcriptional Repression by 1,25-dihydroxyvitamin D₃ in Breast cancer Cells.  The Era of Hope: the Department of Defense Breast Cancer Research Program Meeting, Washington, DC, October 31-November 4,1997.
  
  
• McGaffin KR; Chrysogelos SA.  Regulation of Growth and EGF Receptor Expression in Breast Cancer Cells by Retinoids and Vitamin D.  Abstract submitted to the American Medical Student Association Annual Poster Presentation, 1997.
  
  
• Yan CY; McGaffin KR; Van Dyke TA.  Differential Regulation of the Transthyretin Transgenes in the Developing Mouse Embryo.  Gordon Conference, 1992.
  
  
• McGaffin KR; Van Dyke TA.  Transthyretin and Familial Amyloidotic Polyneuropathy in Transgenic Mice.  University of Pittsburgh Annual Biological Sciences Symposium, August, 1991.

(Back to TOP )

Monsky, Wayne L.

(Graduated 1995 - Cell Biology)

Doctoral Dissertation:

• Invadopodia Associated Proteases (Gelatinase A, Melanomas, Seprin)  

Journal Publications:

• Monsky WL;  Aoyama A;  Kelly T;  Mueller SC; Chen WT.  Identification of 170 kDa membrane gelatinase and membrane associated 72 kDa metallo-gelatinase that are involved with human tumor cell invasiveness.  Cancer Res (submitted).
  
  
• Hobbs SK; Monsky WL; Yuan F; Roberts WG; Griffith L; Torchillin VP; Jain RK.  Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.  Proc Natl Acad Sci 95:4607-12, 1998.
  
  
• Fukumura D; Yuan F; Monsky WL; Chen Y; Jain RK.  Effect of host microenvironment on the microcirculation of human colon adenocarcinoma.  Am J Pathol 151:679-88, 1997.
  
  
• Monsky WL; Lin CY; Aoyama A; Kelly T; Akiyama SK; Mueller SC; Chen WT.  A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells.  Cancer Res 54: 5702-10, 1994.
  
  
• Chen WTJ; Lee CC; Goldstein L; Bernier S; Liu CH; Lin CY; Yeh Y; Monsky WL; Kelly T; Dai M; et al.  Membrane proteases as potential diagnostic and therapeutic targets for breast malignancy.  Breast Cancer Res Treat 31:217-26, 1994.
  
  
• Monsky WL; Chen WT.  Proteases of cell adhesion proteins in cancer.  Semin Cancer Biol 4:251-258, 1993.
  
  
• Monsky WL;  Kelly T;  Lin CY;  Yeh YY;  Stetler-Stevenson WG; Chen WT.  Binding and processing of 72 kDa matrix-metalloproteinase at cell surface invadopodia.  Cancer Res 53:3159-3164, 1993.
  
  
• Colton CA; Keri JE;  Monsky WL; Chen WT.  Protease production by microglia:  substrate-gel analysis and immobilized matrix degradation.  J Neurosci Res 35:297-304, 1993.
  
  
• Crisp TM; Monsky WL.  Maturation of prolactin-mediated progesterone responses in rat granulosa cells by LH during inhibition of steroidogenesis.  J Reprod Endocrinol, 1992.
  
  
• Chen WT; Monsky WL;  Kelly T; Mueller SC; Lin CY; Yeh YY; Stetler-Stevenson WG.  Binding and activation of 72 kDa matrix metalloproteinase (MMP) at sites of the cell surface called invadopodia.  J Cell Biol 1991.
  
  
• Keri J;  Chen WT; Monsky WL; Yao J; Colton C; Gilbert D.  Degradation of immobilized fibronectin-gelatin substrates by LPS and IL-1 stimulated microglia.  Neurosci 1991.
  
  
• Monsky WL; Kelly T; Aoyama A; Chen WT.  Rapid identification of matrix-metalloproteinases and sulfhydryl containing proteases in membrane extracts of human tumor cell lines.  J Cell Biol 1991.

(Back to TOP )

Moulding, Hugh

(Graduated 2002 - Neuroscience)

Doctoral Dissertation:

• Clinical mutations in L1 neural cell adhesion molecule affect trafficking and cell-surface expression   

Journal Publications:

• Simmons DD; Moulding HD; Zee D.  Olivocochlear Innervation of Inner and Outer Hair Cells During Postnatal Maturation: An Immunocytochemical Study.  Dev Brain Res 95:213-226, 1996.
  
  
• Poland RE; McCracken JT; Lutchmansingh P; Heist KE; Moulding HD.  Repeated Scopolamine Treatment Does Not Enhance the ACTH Response to Physostigmine in Rats.  Depression 1:101-4, 1993.

Abstracts:

• Moulding HD; Rabkin SD.  Defective Herpes Simplex Virus Vectors Encoding Normal or Mutant L1 Cell Adhesion Molecules.   Abstr Soc Neurosci, Vol. 24 (1) 412.2, p. 1030, 1998.
  
  
• Moulding HD; Yakovchenko E; Bregman BS.  Both Transplants and Neurotrophic Factors Induce Regrowth of CNS axons and c-Jun Immunostaining in Neuronal Soma After Spinal Cord Lesion in Adult Rats.  National M.D./Ph.D. Conference, July 1995.
  |
  
• Moulding HD; Simmons DD.  Presence of Neuroactive Substances in the Developing Inner Ear.  West Coast Undergraduate Research Conference, May 1993.
  
  
• Simmons DD; Moulding HD; Klein HA.  Presence of Neuroactive Substances in the Postnatal Cochlea.  Abstracts Soc. for Neurosci, Vol. 19(2) 580.9, p. 1420, 1993.

(Back to TOP )

New, Kent

(Graduated 1998 - Microbiology & Immunology)

Doctoral Dissertation:

• Defective herpes simplex virus vectors for gene transfer to cells of the central nervous system: The study of glutamic acid decarboxylase   

Journal Publications:

• New KC; Rabkin SD.  Co-expression of two gene products in the CNS using double-cassette defective herpes simplex virus vectors.  Mol Brain Res 371: 317-23, 1996.
  
  
• Essepian JP; Rajpal R; Azar D; New K; Antonacci R; Shields W; WJ Stark.  The use of confocal microscopy in evaluating corneal wound healing after excimer laster karetectomy.  Scanning 16:300-4, 1994.
  
  
• New KC; Martuza RL; Rabkin SD.  Defective herpes simplex virus vectors for the study of promoter and gene function in the CNS.  Gene Ther 1:S79, 1994.
  
  
• Petroll WM; New KC; Sachdev M; Cavanagh HD; Jester JV.   Radial Keratotomy III:  Relationship between wound gape and corneal curvature in primate eyes.  Invest Ophthalmol Vis Sci 33 (12) :3283-3291, 1992.
  
  
• New KC; Petroll WM; Boyde A; Martin L; Corcuff P; Leveque JL; Lemp MA; Cavanagh HD; Jester JV.  In vivo imaging of human teeth and skin using real-time confocal microscopy.  J Scanning       13:369-372, 1991.

(Back to TOP )

Orford, Keith

(Graduated 2001 - Tumor Biology)

Doctoral Dissertation:

• Beta-catenin over-expression: Cause and effect 

Journal Publications:

• Orford K; Orford CC; Byers SW.  b-catenin regulates contact inhibition, anchorage-independent growth, anoikis and radiation-induced cell cycle arrest.  J  Cell Biol (submitted).
  
  
• Orford K; Crockett C; Jensen JP; Weissman AM; Byers SW.  Serine Phosphorylation regulated Ubiquitination and Degradation of b-Catenin. J Biol Chem 272: 24735-24738, 1997.

Abstracts:

• Orford K; Crockett C; Jensen JP; Weissman AM; Byers SW.  Serine Phosphorylation regulated Ubiquitination and Degradation of b-Catenin. J Biol Chem 272: 24735-24738, 1997.
  
  
• Byers SW; Pishvaian M; Orford K; Sommers C; Leichleider R. An interactive network of retinoid, serine, threonine kinase signalling pathways modulates b-catenin homeostasis. J Cell Biochem Suppl 19A:335, 1995.
  
  
• Lechleider  R; Orford K; Sommers CL; Sporn M; Byers SW.  b-catenin is phosphorylated on serine and threonine and associates with a kinase. Mol Biol  Cell  5:1079, 1994.

(Back to TOP )

Pishvaian, Michael

(Graduated 2001 - Tumor Biology)

Doctoral Dissertation:

• The effects of retinoic acid on the function and expression of components of the adherens junction   

Journal Publications:

• Pishvaian MJ; Feltes CM; Thompson P; Bussemakers MJ; Schalken JA; Byers SW.  Cadherin-11 is expressed in invasive breast cancer cell lines. Cancer Res 59 (in press).
  
  
• Pishvaian MJ; Easwaran V; Byers SW.   9-cis retinoic acid regulates b -catenin/LEF signaling. Genes & Development (submitted).
  
  
• Pishvaian MJ; Byers SW.  Increased cadherin expression, but not increased b -catenin expression is necessary and sufficient to mimic the effects of retinoic acid in breast cancer cells.  J Cell Biol (submitted).
  
  
• Byers S; Pishvaian MJ; Crockett C; Peer C; Tozeren A; Sporn M; Anzano M; Lechleider R.  Retinoids increase cell-cell adhesion strength, beta catenin protein stability, and localization to the cell membrane in abreast cancer cell line. A role for serine kinase activity.  Endocrinology 137: 3265-3273, 1996.

(Back to TOP )

Poling, Jon

(Graduated 1997 - Physiology & Biophysics)

Doctoral Dissertation:

• On the mechanism of potassium channel blockade by polyunsaturated fatty acids and cannabinoids   

Journal Publications:

• Poling JS; Rogawski MA; Salem N Jr; Vicini S.  Anandamide, an andogenous cannabinoid, inhibits Shaker-related voltage-gated K+ channels.  Neuropharmacology 35:983-91, 1996.
  
  Poling JS; Vicini S; Rogawski MA; Salem N Jr.  Docosahexaenoic acid block of neuronal voltage-gated K+ channels: subunit selective antagonism by zinc.  Neuropharmacology 35: 969-82, 1996.
  
  
• Poling JS; Karanian JW; Vicini S; Salem N Jr.  Time- and Voltage- Dependent Block of Delayed Rectifier Potassium Channel by Docosahexaenoic Acid.  Molecular Pharm 47(2):  381-390, 1995.  

(Back to TOP )

Powers, Ciaran

(Graduated 2003 - Tumor Biology)

Doctoral Dissertation:

• Pleiotrophin signaling through PTNR in glioblastoma multiforme    

Journal Publications:

• Butscher WG; Powers C; Olive M; Vinson C; Gardner K.   Coordinate transactivation of the interleukin-2/CD28 response element by c-Rel and ATF-1/CREB2.  J Biol Chem 273: p552-60, 1998.
  
  
• Powers C; Krutzsch H; Gardner K.  Modulation of JunD/AP-1 DNA binding activity by AP-1 associated factor 1 (AF-1).  J Biol Chem 271: p30089-95, 1996.

(Back to TOP )

Schlichting, Joyce

(Graduated 1991 - Pharmacology)

Doctoral Dissertation:

• Heterogeneity of GABA(A) Receptors: Differences in the Pharmacological Profiles of Benzodiazepine Recognition Site Ligands 

(Back to TOP )

Tuveson, Anne

(Graduated 2000 - Tumor Biology)

Doctoral Dissertation:

• The regulation and function of the fibroblast growth factor binding protein (FGF-BP) in colon adenocarcinoma   

Journal Publications:

• Tuveson AT;  Aigner A; Cabal R; Czubayko F; Wellstein A.  A rate-limiting role of an FGF binding protein in colon cancer angiogenesis.  Proc Natl Acad Sci (submitted).
  
  
• Czubayko F; Liaudet-Coopman EDE; Aigner A; Tuveson AT; Berchem G; Wellstein A.  A secreted FGF-binding protein can serve as the angiogenic switch in human cancer. Nat Med 3:1137-40, 1997.

(Back to TOP )

Return to M.D./Ph.D. Program main page.

Return to M.D./Ph.D. About our Alumni page.

(Back to TOP )